February 3, 2021   |   by admin

Kollicoat IR®, a new pharmaceutical excipient developed as a coating polymer for instant release tablets, was evaluated as a carrier in solid dispersions of. Kollicoat® IR, a graft copolymer comprised of polyethylene glycol and polyvinyl alcohol (PEG: PVA, ), has been used as an instant release. Cech T., Kolter K. , Influence of plasticizer on the film properties of HPMC and PVA and comparison of the results with the properties of Kollicoat® IR as.

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Choose your language This site is available in the following languages: In a subsequent investigation, Yarkala et al. Thus, PEG-PVA with remarkable properties as binder and coating polymer, and free of peroxides, brings a new generation of excipient that could be widely applied to a range of wet granulation formulation development of highly sensitive drugs prone to oxidative degradation. As wet binderit combines powerful binding with no peroxides at all. Based on a work at https: MedCrave Group Danforth Rd.

You will find the unsubscribe link at the end of each newsletter you receive. Controlling the residual peroxides is therefore critical to improve kollicooat term stability and to maintain the quality of pharmaceutical dosage forms, and the research continues to find the optimal solutions. These impurities may lead to undesired reactions and alter the efficacy of dosages with possibly adverse effects [3].


A further study suggests that the formation of N-oxide was not limited to formulation only but was also observed in the synthesis of raloxifene [17]. Due to its low viscosity values in aqueous solutions, easy processing in a vast process parameter range is assured.

J Anal Pharm Res 2 3: For instance, wet granulation though remains widely practiced in the industry for its simplicity and easy scale up, can exert an enormous mechanical stress on the excipients caused by multiple formulation steps involving blending, mixing, granulation, drying, and sieving [4].

Kollicoat® IR: Minimizing the Risks for Oxidative Degradation of Drugs

HelloYou are logged in with access to additional information. Link to reset your password has been sent to jr provided E-Mail ID. Taken collectively, this study also demonstrates that PEG-PVA was exceptionally stable and did not show a peroxide increase under the various ambient stability conditions over a 5 years period. Binders are important ingredients of solid oral dosage formulations SODFs.

Wet binder in formulation of ascorbic acid tablet The properties of PEG-PVA as a binder have been evaluated in wet and fluid bed granulations []. Granule properties such as particle size and compression profile were evaluated, and kkllicoat with copovidone and HMPC granules. Industry Please choose your industry.

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Unless noted otherwise, the statistical analysis was not performed as all the data points were a single measurement on each individual samples. Those residual peroxides typically originate during the manufacturing process and get carried over practically in many of the excipients used in formulation.

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By using our services, you agree to our use of cookies. With increasing amounts of peroxides spiked with hydrogen peroxide ur formation of N-oxide increased causing a significant loss inpotency of drug [5].

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Oxidative degradation of raloxifene may lead to adverse reactions [18]. Please choose your subindustry. April 22, Published: This study is aimed at examining the impact of peroxides on degradation of drug in formulations prepared by wet granulation and finds the appropriate excipients to mitigate the risks for degradation.

Please provide a valid registered E-Mail ID. Thus, minimizing the risks for elevated impurities in the excipients, especially the peroxides, is highly essential, which could otherwise be detrimental to long term stability of pharmaceutical dosages [5 6].

Tablet properties such as tablet weight, thickness, hardness, friability, and disintegration time with PEG-PVA and povidoneK30 were evaluated and found to be comparable with both binders with the individual corresponding amounts used. Back to registration form. The hardness of the granules, increased as a function of compression forces in both fluid bed and high shear granulations.